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For instance, disruption of client retrograde retrieval due to mutations in COPA, the human ortholog of -COPI, underlies the autoimmune COPA syndrome, which causes coughing, shortness of breath, lung inflammation and scarring, pulmonary hemorrhaging, and systemic autoimmune reactions such as arthritis 46

Balmaceda JP, Bernardini L, Ciuffardi I, Felix C, Ord T, Sueldo CE, et al

Zonulin family peptide (zonulin), a potent regulator for intestinal tight junctions, is highly expressed in autoimmune mice and humans and can be used to predict transition from autoimmunity to inflammatory arthritis